Differential proteomics of human seminal plasma: A potential target for searching male infertility marker proteins

The clinical fertility tests, available in the market, fail to define the exact cause of male infertility in almost half of the cases and point toward a crucial need of developing better ways of infertility investigations. The protein biomarkers may help us toward better understanding of unknown cases of male infertility that, in turn, can guide us to find better therapeutic solutions. Many clinical attempts have been made to identify biomarkers of male infertility in sperm proteome but only few studies have targeted seminal plasma. Human seminal plasma is a rich source of proteins that are essentially required for development of sperm and successful fertilization. This viewpoint article highlights the importance of human seminal plasma proteome in reproductive physiology and suggests that differential proteomics integrated with functional analysis may help us in searching potential biomarkers of male infertility.     

气膜片胀形模结构的改进

分析了气膜片零件胀形质量差的原因，对原模具结构进行了改进，解决了原模具成形后贴模不理想、型面不准确的问题，提高了零件质量。     

喷雾干燥法生产无菌原料药的质量风险与控制

喷雾干燥在药品生产中应用较多,喷雾干燥塔分为离心式、气流式、压力式,传统的喷雾干燥法生产无菌原料药过程中在不溶性微粒、无菌、均一性、有效成分降解等方面存在质量风险,应该针对性地在设备设计、清洁、灭菌、无菌粉冷却、混粉、环境控制等方面对各种风险加以严格控制,才能有效地生产出高品质的无菌原料药。     

Effects of larval crowding and nutrient limitation on male phenotype,reproductive investment and strategy in Ephestia kuehniella Zeller (Insecta: Lepidoptera)

Food shortage experienced by juvenile insects affects adult morphology and life-history traits. Developmental plasticity and trade-off between ecological and sexual traits helps maximise individual fitness. Ephestia kuehniella were reared at different larval densities to investigate phenotypic shifts in adult males. Variation in ecological traits (sizes of forewing, head and thorax and adult longevity) and sexual traits (valva and aedeagus, sperm number, mating frequency) were compared. Males that emerged from highest density population (800) had lower body mass and small forewings, head and thorax, suggesting that they could not completely compensate for food shortage. The allometric relationship between body mass and forewing length also changed, and these males had relatively longer wings. This arrangement may enhance dispersal and assist in mate-searching at higher densities. Males from all larval densities achieved similar mating frequency but those from higher density produced fewer eupyrene sperm and had shorter adult lifespan. By mating more frequently and maintaining apyrene sperm production, males increase their reproductive success at sperm competition observed at higher densities. Food stress associated with high density populations did not affect valva and aedeagus size indicating that these traits may be insensitive to external environmental changes because they incur fitness costs to males.     

基于LC-Triple TOF MS/MS技术分析杜仲不同药用部位化学成分差异

为探讨杜仲不同药用部位(杜仲、杜仲叶和杜仲雄花)化学成分的差异,采用液相色谱-串联三重四极杆飞行时间高分辨质谱(LC-Triple TOF MS/MS)结合多元统计分析技术对杜仲不同药用部位的化学成分进行差异分析。通过对多级串联质谱数据进行峰匹配、峰对齐、滤噪处理等分析,提取特征峰;用聚类分析(HCA)、主成分分析(PCA)和偏最小二乘法-判别分析(PLS-DA)进行数据处理;通过一级质谱精确质荷比和二级质谱碎片信息,结合软件数据库搜索、标准品比对及相关文献进行成分鉴定。结果显示:杜仲、杜仲叶与杜仲雄花三者的化学组成可得到明显区分;初步筛选鉴定出23种差异显著的化学成分,且呈现不同的变化规律。杜仲、杜仲叶及杜仲雄花化学成分的差异及其变化规律,可为揭示三者药效差异的物质基础提供依据。     

Could sperm quality be affected by a building environment? A literature review

The human body responds psychologically and physiologically to the thermal environment to which it is exposed. Fanger's PMV model has been adopted for the design of built environments and building maintenance from the end of the 1960s. The sperm quality of humans has been decreasing since the 1970s. The thermal environment is one of the most important factors of the Sick Building Syndrome (SBS). It is well known that spermatogenesis is very sensitive to heat exposure. Mild thermal exposure increases tissue microcirculation and consequently produces an appropriate supply of nutrients and oxygen to tissue cells; thus, it can modulate the proliferation of Sertoli cells in which the spermatogonia stem cells develop into adult spermatozoa. Excessive exposure to heat is harmful to spermatogenesis, and excessive testicular cooling can cause the cessation of spermatogenesis.     

中国核农学的发展历程与成就

文章概述了我国核农学的创建与发展历程以及核技术农业应用研究所取得的主要成果。我国核农学始于1956年，经过50多年的发展，现已形成科研协作网络、学术交流网络、国际交流网络。这三大网络全面推动了中国农业核技术应用的核农学的形成与发展，在辐射育种、航天育种、同位素示踪技术在农业中的应用、农产品辐照贮藏和保鲜加工、辐射害虫防治、低剂量辐射刺激增产等方面取得了显著成绩。此外，文章还就中国核农学今后的发展构想以及核农学优先发展的主要领域提出了构思和建议。     

Decolorization of textile dyes by Bjerkandera sp. BOL 13 using waste biomass as carbon source

BACKGROUND: Phanerochaete chrysosporium, Trametes versicolor and Bjerkandera sp BOL13 were compared for decolorization of azo dyes supplied individually or as a mixture. The dye decolorization was also evaluated during continuous treatment under non‐sterile conditions using a lignocellulosic growth substrate. RESULTS: Bjerkandera sp BOL13 showed the highest dye decolorization potential. This fungus was also found to support high decolorization of Remazol Red RR at an initial pH of 4‐6 and when using straw as co‐substrate. The fungus was evaluated for Remazol Red RR decolorization in a continuously fed packed‐bed bioreactor operated under non‐sterile conditions with 3 days of hydraulic retention time. When glucose was supplied as growth‐substrate, decolorization efficiencies of 65‐90% were maintained for 12 days in a bioreactor packed with wooden material. The decolorization efficiency was lower when glucose was not fed to the fungus or when a plastic material was used as packing. Higher manganese peroxidase and laccase activities were also recorded when the wood packing was used. Contamination caused a drop in decolorization efficiency after 17‐19 days operation. CONCLUSIONS: The potential of Bjerkandera sp BOL13 for decolorization of azo dyes under non‐sterile conditions using lignocellulosic growth substrates was demonstrated. Research is needed to reduce contamination under non‐sterile conditions. © 2012 Society of Chemical Industry     

男西裤形态尺寸与舒适性关系的研究

本文主要研究男西裤形态尺寸与行动舒适性的关系。经研究表明,西裤的形态尺寸不仅影响西裤的外观,而且关系到行动的舒适性,据此提出了改进西裤结构设计的方向性建议。     

一种无菌培养基温度测量装置的设计研究

本研究设计制作了一种针对生物实验室中无菌培养基的温度测量系统以及相应的报警系统.包括整体方案,硬件电路以及软件设计,并给出了参考的产品外观建议.该数字温度测量系统的外部电路简单,具备低成本易使用的特点.